Spatial genome organization and cognition

Testosterone: activation or organization of spatial cognition?

Previous studies in animals have revealed effects of both prenatal and current testosterone on brain organization and behavior. However, it is unclear how these effects translate to the human brain. Here, we refine previous procedures to clarify the relative contribution of prenatal versus current testosterone indices to cognitive function. Sixty-nine subjects performed four computerized tasks ...

Understanding Spatial Genome Organization: Methods and Insights

The manner by which eukaryotic genomes are packaged into nuclei while maintaining crucial nuclear functions remains one of the fundamental mysteries in biology. Over the last ten years, we have witnessed rapid advances in both microscopic and nucleic acid-based approaches to map genome architecture, and the application of these approaches to the dissection of higher-order chromosomal structures...

Spatial Cognition, Spatial Perception

“Where am I? Where am I going? How do I get there?” These are the questions on the minds of Spatial Cognition, Spatial Perception’s authors. And since this reviewer has chosen to write his review on location in a remote and unfamiliar city while traveling for a conference, such questions are on my mind as well. As my enormous human prefrontal cortex and conveniently opposable thumbs allow me to...

Breast Cancer Diagnostics Based on Spatial Genome Organization

Thermodynamic pathways to genome spatial organization in the cell nucleus.

The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex patterns requiring the orchestration of a huge number of DNA loci and molecular regulators. Far from random, this organization serves crucial fun...